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 Marcia Purse

Zyprexa Injections Investigated by FDA After 2 Deaths

By June 18, 2013

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Zyprexa Injections Under InvestigationThe injectable form of the antipsychotic Zyprexa, called Zyprexa Relprevv (olanzapine pamoate) is under investigation by the US Food and Drug Administration after two patients died after receiving the injections.

According to the FDA, the patients received the appropriate dose and were monitored as required for three hours after the injection before being allowed to go home. However, both patients died 3-4 days after receiving the injections, so the FDA cannot be sure whether Zyprexa Relprevv was related to the deaths.

Possible complications from these injections include post-injection delirium sedation syndrome (PDSS), a serious condition in which the drug enters the blood too fast following an intramuscular injection, causing greatly elevated blood levels with marked sedation (possibly including coma) and/or delirium. During clinical trials, this condition occurred in some patients within 3 hours after injection - hence the mandatory 3-hour waiting and monitoring period. In trials, there were no reports of problems occurring after 3 hours. There were no deaths during the trials.

Both patients who died had high levels of olanzapine in their systems, but this by itself is not sufficient evidence to determine cause and effect. The FDA is not recommending discontinued use of the drug at this time.

I need to stress that the pill forms of Zyprexa are not being investigated. The FDA statement applies only to the Zyprexa Relprevv injection form.

Image: Jonnie Miles / Getty Images
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Comments
June 18, 2013 at 11:42 pm
(1) Daniel Haszard says:

Thanks for posting this vital information.The Eli Lilly company made an astounding $70 BILLION on Zyprexa that they PUSHED on the elderly and underage children (*Viva Zyprexa* Lilly sales rep slogan) with wanton disregard for the side effects

*FIVE at FIVE*
The Zyprexa antipsychotic drug,whose side effects can include weight gain and diabetes, was sold to Veterans,children in foster care, elderly in nursing homes.
*Five at Five* was the Zyprexa sales rep slogan, meaning *5mg dispensed at 5pm would keep patients quiet*.
– Daniel Haszard

June 25, 2013 at 11:39 am
(2) patti chucka says:

Once again the mentally I’ll are used as human guinea pigs. What do they mean they cannot be sure if this drug caused their. R they kidding. Thanks for the info

June 25, 2013 at 4:23 pm
(3) rebecca says:

A horrid drug even in pill form. It can certainly stabilize your mood but the side effects simply outweigh the benefits. I stayed on it way too long because I was scared of trying something else. It was worth that risk. My mood is actually more stable and i can keep my hair, insulin levels, and stay awake for more than five hours at a time. Zyprexa was supposed to be an emergency mania measure. Not worth it for long term. Obviously TALK TO YOUR DOCTOR. DO NOT STOP BY YOURSELF.

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