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 Marcia Purse

New Antipsychotic Drug Latuda Better for Your Weight

By March 11, 2014

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Latuda, a fairly new antipsychotic, has been shown to be effective in treating schizophrenia and has now been approved for use in bipolar depression. The three other atypical antipsychotics - Seroquel, Zyprexa and Symbyax - that are already approved for bipolar depression all have problems with side effects - particularly on weight gain and the related metabolic issues of increased blood glucose and elevated cholesterol and triglycerides.

Latuda, by contrast, is considered weight neutral. In clinical trials of lurasidone (Latuda's generic name), weight gain was less than a quarter of that gained by patients taking olanzapine (Zyprexa). The conclusion was that "Overall, the effects of lurasidone on increasing the risk of developing metabolic syndrome is minimal."

In May 2012, a pooled analysis of six studies found that while 12% of 371 patients had gained weight, 28.6% of patients had their weight status changed from overweight to normal weight. The study authors said the results showed that patients who started out overweight or obese were more likely to lose weight than those who were underweight or normal weight at the beginning.

This is not to say Latuda is a wonder drug for weight loss, but so far the indications are promising, especially since the overall side effect profile is basically the same as for other atypical antipsychotics.

More information: Latuda Drug Profile

Sources:
Ehret, MJ, et al. Focus on lurasidone: A new atypical antipsychotic for the treatment of schizophrenia. Formulary. 1 Nov 2010.
Meyer, JM, et al. Lurasidone Not Associated With Weight Gain in Patients With Schizophrenia. May 2012.

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Comments
August 20, 2012 at 1:57 pm
(1) Daniel Haszard says:

There is a case to be made that the drug companies like Eli Lilly,knew exactly what they were doing to off-label Zyprexa.Zyprexa made them $65 billion dollars they paid no more than $4 billion in fines and lawsuits.-Daniel Haszard Zyprexa victim advocate.

Tell the truth don’t be afraid

August 20, 2012 at 1:58 pm
(2) Daniel Haszard says:

Yes,be aware of drugs that potentiate diabetes.
Eli Lilly Zyprexa Olanzapine issues linger.
The use of powerful antipsychotic drugs has increased in children as young as three years old. Weight gain, increases in triglyceride levels and associated risks for diabetes and cardiovascular disease. The average weight gain (adults) over the 12 week study period was the highest for Zyprexa—17 pounds. You’d be hard pressed to gain that kind of weight sport-eating your way through the holidays.One in 145 adults died in clinical trials of those taking the antipsychotic drug Zyprexa.
This was Lilly’s #1 product $5 billion per year sales,moreover Lilly also make billions more on drugs that treat diabetes.
— Daniel Zyprexa activist and patient.

November 15, 2012 at 1:03 am
(3) Chris says:

Zyprexa/Olanzapine is a Diabetic Anti Psychotic!

March 13, 2014 at 6:19 pm
(4) Jeff C says:

All drugs have some side effects. If Zyprexa prevents my loved one from committing suicide or mayhem, and brings their personality back to life, then it is worth a risk of diabetes!! Drug researchers are trying very hard to come up with new drugs to alleviate symptoms. Some work well, some don’t, all have side effects.

March 22, 2014 at 10:09 am
(5) Dee says:

Zyprexa caused PERMANENT liver damage to my son. All it ever did was zonk him out. Try Lamictal and get your loved one back with NO weight gain.

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