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Sinequan / Doxepin / Adapin Side Effects

Bipolar Medications Library


Updated September 22, 2006

Catalogue of side effects for the medication Doxepin, sold under the brand names Sinequan, Adapin and others, which is a tricyclic antidepressant and antianxiety drug sometimes prescribed for use in treating bipolar and other mood disorders.

Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

Dizziness; drowsiness; dryness of mouth; headache; increased appetite (may include craving for sweets); nausea; tiredness or weakness (mild); unpleasant taste; weight gain

Less Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

Diarrhea; heartburn; increased sweating; trouble in sleeping (more common with protriptyline, especially when taken late in the day); vomiting

Always Notify Doctor:

Less Common: Blurred vision; confusion or delirium; constipation (especially in the elderly); decreased sexual ability (more common with amoxapine and clomipramine); difficulty in speaking or swallowing; eye pain; fainting; fast or irregular heartbeat (pounding, racing, skipping); hallucinations; loss of balance control; mask-like face; nervousness or restlessness; problems in urinating; shakiness or trembling; shuffling walk; slowed movements; stiffness of arms and legs

Rare: Anxiety; breast enlargement in both males and females; hair loss; inappropriate secretion of milk - in females; increased sensitivity to sunlight; irritability; muscle twitching; red or brownish spots on skin; ringing, buzzing, or other unexplained sounds in the ears; seizures (more common with clomipramine); skin rash and itching; sore throat and fever; swelling of face and tongue; swelling of testicles (more common with amoxapine); trouble with teeth or gums (more common with clomipramine); weakness; yellow eyes or skin

Overdose Effects - Notify Doctor:

Confusion; convulsions (seizures); disturbed concentration; drowsiness (severe); enlarged pupils; fast, slow, or irregular heartbeat; fever; hallucinations (seeing, hearing, or feeling things that are not there); restlessness and agitation; shortness of breath or troubled breathing; unusual tiredness or weakness (severe); vomiting

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Further Reading

  1. About.com
  2. Health
  3. Bipolar Disorder
  4. Medications
  5. Antidepressants
  6. Tricyclics
  7. Doxepin
  8. Side Effects - Doxepin / Sinequan / Adapin - Bipolar Disorder Medications

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