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Trilafon / Perphenazine Side Effects

Bipolar Medications Library

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Updated June 26, 2014

Trilafon - generic Perphenazine - is used in the management of psychotic disorders such as schizophrenia, bipolar disorder and agitated depression. It also is used for the management of severe nausea and vomiting and as a tranquilizer to help agitated and disruptive behavior.

Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

Constipation; decreased sweating; dizziness; drowsiness; dryness of mouth; nasal congestion

Less Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

Changes in menstrual period; decreased sexual ability; increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin, or severe sunburn); swelling or pain in breasts; unusual secretion of milk; weight gain (unusual)

SPECIAL WARNING:

Along with their needed effects, phenothiazines can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Stop taking this medicine and check with your doctor immediately if any of the following side effects occur:

Rare:

Convulsions (seizures); difficult or fast breathing; fast heartbeat or irregular pulse; fever; high or low blood pressure; increased sweating; loss of bladder control; muscle stiffness (severe); unusually pale skin; unusual tiredness or weakness

Notify Doctor Immediately:

More Common: Lip smacking or puckering; puffing of cheeks; rapid or fine, worm-like movements of tongue; uncontrolled chewing movements; uncontrolled movements of arms or legs

Notify Doctor As Soon As Possible:

More Common: Blurred vision, change in color vision, or difficulty in seeing at night; difficulty in speaking or swallowing; fainting; inability to move eyes; loss of balance control; mask-like face; muscle spasms (especially of face, neck, and back); restlessness or need to keep moving; shuffling walk; stiffness of arms or legs; tic-like or twitching movements; trembling and shaking of hands and fingers; twisting movements of body; weakness of arms and legs

Less Common: Difficulty in urinating; skin rash; sunburn (severe)

Rare: Abdominal or stomach pains; aching muscles and joints; confusion; fever and chills; hot, dry skin or lack of sweating; muscle weakness; nausea, vomiting, or diarrhea; painful, inappropriate penile erection (continuing); skin discoloration (tan or blue-gray); skin itching (severe); sore throat and fever; unusual bleeding or bruising; yellow eyes or skin

Withdrawal Side Effects - Notify Doctor:

Dizziness, nausea and vomiting, stomach pain, trembling of the fingers and hands, or any of the following symptoms of tardive dyskinesia: Lip smacking or puckering; puffing of cheeks; rapid or fine, worm-like movements of tongue; uncontrolled chewing movements; uncontrolled movements of arms or legs

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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  7. Trilafon (Perphenazine) Bipolar Medication Side Effects

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