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Loxapine / Loxitane / Loxapac Side Effects

Bipolar Medications Library


Updated July 15, 2006

Loxapine is an antipsychotic medication sold under the brand names Loxitane (United States) and Loxapac (Canada). This drug may be used to manage the psychotic features of bipolar disorder, schizophrenia, etc.

Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

Blurred vision; confusion; dizziness, lightheadedness, or fainting; drowsiness; dryness of mouth

Less Common Side Effects:

Check with your doctor if any of the following side effects continue or are bothersome:

Constipation (mild); decreased sexual ability; enlargement of breasts (males and females); headache; increased sensitivity of skin to sun; missing menstrual periods; nausea or vomiting; trouble in sleeping; unusual secretion of milk; weight gain


Along with its needed effects, loxapine can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Stop taking loxapine and get emergency help immediately if any of the following side effects occur:


Convulsions (seizures); difficult or fast breathing; fast heartbeat or irregular pulse; fever (high); high or low blood pressure; increased sweating; loss of bladder control; muscle stiffness (severe); unusually pale skin; unusual tiredness or weakness

Notify Doctor Immediately:

More Common: Lip smacking or puckering; puffing of cheeks; rapid or fine, worm-like movements of tongue; uncontrolled chewing movements; uncontrolled movements of arms or legs

Notify Doctor As Soon As Possible:

More common (occurring with increase of dosage): Difficulty in speaking or swallowing; loss of balance control; mask-like face; restlessness or desire to keep moving; shuffling walk; slowed movements; stiffness of arms and legs; trembling and shaking of fingers and hands

Less Common: Constipation (severe); difficult urination; inability to move eyes; muscle spasms, especially of the neck and back; skin rash; twisting movements of the body

Rare: Sore throat and fever; increased blinking or spasms of eyelid; uncontrolled twisting movements of neck, trunk, arms, or legs; unusual bleeding or bruising; unusual facial expressions or body positions; yellow eyes or skin

Withdrawal Side Effects - Notify Doctor:

Dizziness; nausea and vomiting; rapid or worm-like movements of the tongue; stomach upset or pain; trembling of fingers and hands; uncontrolled chewing movements

Overdose Effects - Notify Doctor:

Dizziness (severe); drowsiness (severe); muscle trembling, jerking, stiffness, or uncontrolled movements (severe); troubled breathing (severe); unusual tiredness or weakness (severe)

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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  7. Side Effects - Loxapine / Loxitane / Loxapac - Bipolar Disorder Medications

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